Muscle/nerve biopsy special studies

Routine workup

  • Skeletal muscle biopsies
    • Light microscopy
      • Formalin-fixed paraffin processed
        • H & E
        • Thioflavine S
      • Histochemical stains on frozen sections
        • Gomori trichrome
        • Periodic acid Schiff (PAS)
        • NADH-tetrazolium reductase (NADH-TR)
        • ATPase, pH 9.4
        • Modified succinate dehydrogenase (SDH)
  • Peripheral nerve biopsies
    • Light microscopy
      • Formalin-fixed paraffin processed
        • H & E
        • Thioflavine S
    • Glutaraldehyde-fixed, plastic resin processed
      • Semi-thin sections, toluidine blue O stain

Additional studies

  • Formalin-fixed paraffin processed
    • Masson’s trichrome
    • Periodic acid Schiff (PAS)
    • Periodic acid Schiff (PAS)—diastase pretreatment
  • Histochemical stains on frozen sections
    • Oil red O
    • Periodic acid Schiff (PAS)—diastase pretreatment
    • Modified Congo red (Mendell)
    • ATPase, pH 4.3
    • ATPase, pH 4.6
    • Cytochrome c oxidase
    • Myoadenylate deaminase
    • Myophosphorylase
    • Phosphofructokinase
    • Acid phosphatase
    • Non-specific esterase
  • Immunohistochemical stains on frozen sections
    • Dystrophin, amino-terminus
    • Dystrophin, rod domain
    • Dystrophin, carboxy-terminus
    • Utrophin
    • Alpha-sarcoglycan
    • Dysferlin
    • Merosin
    • Spectrin
    • Alpha-dystroglycan, glycosylated (immunofluorescence)
    • Caveolin-3 (immunofluorescence)
  • Electron microscopy
 
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