ARUP's Laboratory Test Directory

0020598: Wilson Disease Screening Panel, Serum

Test Mnemonic: WILSON D
Methodology: Immunoturbidimetric/Inductively Coupled Plasma/Mass Spectrometry

Performed: Refer to individual components

Reported: Refer to individual components

Specimen Required:  
Collect: One 6 mL royal blue (no additive).

Transport: 4 mL serum, frozen. (Min: 2.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 2.5 serum, frozen.

Remarks: Centrifuge and pour off serum into an ARUP Standard Transport Tube ASAP.  Do not allow serum to remain on cells.

Unacceptable Conditions: Separator tubes and specimens that are not separated from the red cells or clot.

Stability: After separation from cells: Ambient: 8 hours; Refrigerated: 3 days; Frozen: 1 month

Reference Interval:
 
Test Number Components Reference Interval
0020096Copper, Serum  
 
Age Male Female
0 up to 6 months 20-70 µg/dL 20-70 µg/dL
7 months-18 years 90-190 µg/dL 90-190 µg/dL
19 years and older 70-140 µg/dL 80-155 µg/dL
0050160Ceruloplasmin 0-17 years: 20-43 mg/dL
18 years and older: 17-54 mg/dL
0020596Copper, Serum Free (Direct) Less than 6.2 µg/L

Interpretive Data:
Free copper (direct) is determined with serum ultrafiltrate.  In Wilson disease or other conditions of copper overload, serum ceruloplasmin is usually low and free copper (direct) is usually high.  Other tests used to diagnosis Wilson disease include 24-hour urine copper, and hepatic copper.  Slit lamp examination for Kayser-Fleischer rings and genetic testing may also be helpful.



Note:
Elevated results from tubes not certified metal-free may be due to contamination.  Elevated levels should be confirmed with a second specimen collected in a metal-free tube.

CPT Code(s):
82390 Ceruloplasmin; 82525 Copper; 82525 Copper, free (direct)