ARUP's Laboratory Test Directory

Varicella-Zoster Virus Antibody, IgG : 0050167

Mnemonic: VZE

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Sun, Tue-Sat
Reported: Within 24 hours
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum an ARUP Standard Transport Tube. (Min: 0.1 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or icteric specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
0.89 IV or less: Negative - No significant level of detectable varicella-zoster IgG antibody.
0.90-1.09 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past varicella-zoster infection. Positive IgG antibody levels in the absence of current clinical symptoms may indicate immunity (98% correlation with IFA).
Interpretive Data: The best evidence for current infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.
CPT Code(s): 86787
Cross References: Chickenpox (Varicella-Zoster Virus Antibody, IgG), Herpes Zoster (Varicella-Zoster Virus Antibody, IgG), Shingles (Varicella-Zoster Virus Antibody, IgG), VZV Antibody, IgG (Varicella-Zoster Virus Antibody, IgG)
 
 

 

 

 
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