Reference Interval:
Antibody concentrations of > 0.1 IU/mL are usually considered protective for diphtheria or tetanus.
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| Interpretive Data: |
Responder status is determined according to the ratio of a one-month post-vaccination sample to pre-vaccination concentration of IgG antibodies as follows:
Diphtheria and tetanus:
1. If the post-vaccination concentration is less than 1.0 IU/mL, the patient is considered a nonresponder.
2. If the post-vaccination concentration is greater than or equal to 1.0 IU/mL, a patient with a ratio of less than 1.5 is a nonresponder, a ratio of 1.5 to less than 3.0, is a weak responder, and a ratio of 3.0 or greater, is a good responder.
3. If the pre-vaccination concentration is greater than 1.0 IU/mL, it may be difficult to assess the response based on a ratio alone. A post-vaccination concentration above 2.5 IU in this case is adequate.
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| CPT Code(s): |
86317 Diphtheria; 86317 Tetanus
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Cross References: |
Immune Response (Diphtheria & Tetanus Antibodies, IgG), Tetanus/Diphtheria Antibodies (Diphtheria & Tetanus Antibodies, IgG), Tetanus/Diptheria Vaccine Response (Diphtheria & Tetanus Antibodies, IgG), Vaccine Response (Diphtheria & Tetanus Antibodies, IgG) |