Reference Interval:
0.8 IV or less: Negative - No significant level of Treponema pallidum IgM antibody detected.
0.9-1.1 IV: Equivocal - Questionable presence of Treponema pallidum IgM antibody detected. Repeat testing 10-14 days may be helpful.
1.2 IV or greater: Positive - Presence of IgM antibody to Treponema pallidum detected, suggestive of current or recent infection.
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| Interpretive Data: |
The CDC recommends initial syphilis screening using a non-treponemal assay, such as RPR, prior to confirmation with a treponemal method such as this ELISA or TP-PA.
Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are performed in the same laboratory at the same time. IgM testing is a useful diagnostic aid in differentiating maternally derived IgG antibodies that cross the placenta from IgM antibodies of an active infection in the newborn. Sensitivity in IgM testing for congenital syphilis is 80 percent, therefore, a negative IgM does not necessarily rule out the possibility of congenital syphilis.
Refer to Statement D under Testing Information at http://www.aruplab.com.
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| CPT Code(s): |
86780
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Cross References: |
Syphilis Antibody (Treponema pallidum Antibody, IgM by ELISA)
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