Reference Interval:
Negative
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| Interpretive Data: |
Neutrophil-associated antibodies may cause neutropenia in various autoimmune disorders including Felty's syndrome, SLE and drug-induced neutropenia. Febrile transfusion reactions and isoimmune neonatal neutropenia may also be caused by antibodies to neutrophil-specific antigens or HLA antigens.
A positive result on this test is not definitive for specific anti-neutrophil antibodies, since anti-HLA antibodies and immune complexes may also cause a positive result. The results of this test should be correlated to clinical history and other data.
Refer to Statement A under Testing Information at http://www.aruplab.com.
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| Note: |
Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as "weakly positive" and greater than 3 standard deviations as "positive".
This test should not be confused with Anti-Neutrophil Cytoplasmic Antibody, IgG (0050811 - ANCA).
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| CPT Code(s): |
86021
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Cross References: |
Anti-Granulocyte Antibodies (Neutrophil-Associated Antibodies), Anti-Neutrophil Antibodies (Neutrophil-Associated Antibodies), Granulocyte Ab (Neutrophil-Associated Antibodies), Neutrophil Antibody (Neutrophil-Associated Antibodies) |