ARUP's Laboratory Test Directory

Hepatocellular Carcinoma Tumor Marker Panel : 0081326

Mnemonic: HEP CAR

Methodology: Quantitative Liquid-Phase Binding Immunoassay
Performed: Refer to individual components
Reported: 3-6 days
Specimen Required: Collect: Plain red or serum separator tube.

Specimen Preparation: Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma

Stability (collection to initiation of testing): After separation from cells: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 3 months (avoid repeated freeze/thaw cycles)

Reference Interval:
 
Test Number Components Reference Interval
 Alpha Fetoprotein Total 0-15 ng/mL
 Alpha Fetoprotein L3 Percent 0-9.9 percent
0081312Des-gamma-carboxy Prothrombin By report

Interpretive Data: The µTASWako method is used. Results obtained with different assay methods or kits cannot be used interchangeably.

The AFP-L3 Percent assay is intended as a risk assessment for the development of hepatocellular carcinoma in patients with chronic liver diseases.
Patients with elevated serum AFP-L3 percent should be more intensely evaluated for evidence of hepatocellular carcinoma since elevated values have been shown to be associated with a seven-fold increase in the risk for developing hepatocellular carcinoma within 21 months. For pregnant females, the result is not interpretable as a tumor marker.

The des-gamma-carboxy prothrombin (DCP) assay is intended as a risk assessment for the development of hepatocellular carcinoma in patients with chronic liver diseases. Elevated DCP values have been shown to be associated with an increased risk for developing hepatocellular carcinoma. Patients with elevated serum DCP should be more intensely evaluated for evidence of hepatocellular carcinoma.
CPT Code(s): 82107 AFP L3; 83951 DCP
Cross References: Alpha Fetoprotein, Total & L3 Percent Tumor Marker (Hepatocellular Carcinoma Tumor Marker Panel), Des-Gamma-Carboxy Prothrombin Tumor Marker (Hepatocellular Carcinoma Tumor Marker Panel)
 
 

 

 

 
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