Reference Interval:
Report components include: DNA content, S-phase interpretation, and copy of histogram.
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| Interpretive Data: |
The diagnostic and prognostic importance of tumor DNA content depends on the tumor type and source of tissue. Interpretive information, if available for the tumor type, is included with the DNA histogram.
Refer to Statement B under Testing Information at http://www.aruplab.com.
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| Note: |
A thin section of each tissue submitted is stained with H & E to verify the presence of tumor. The DNA content of each tumor is classified as diploid, near-diploid, tetraploid, aneuploid, hypertetraploid, or hypodiploid. The DNA index is the ratio of tumor G0-G1 cells to normal G0-G1 cells.
The tumor-specific S-phase is used when possible. An average histogram S-phase is used for diploid, near-diploid and hypodiploid tumors where the tumor and host S-phases cannot be separated. An average histogram S-phase is also used when the percentage of aneuploid cells in the histogram is low (less than 25%). The S-phase interpretation is based on comparison to other tumors of the same type, controlled for histogram type (diploid, near-diploid, aneuploid) and sample type (fresh/frozen, paraffin, etc.). The appropriate population is divided into thirds and compared to the sample S-phase for an interpretation of low, moderate, or high S-phase.
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| CPT Code(s): |
88182
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