Reference Interval:
By report
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| Interpretive Data: |
Background Information for HLA-B Sequencing:
Purpose: To identify HLA-B allelic polymorphisms at the level of individual nucleotides.
Methodology: PCR followed by HLA-B sequencing.
Analytical Sensitivity & Specificity: 99 percent.
Limitations: If fewer than 2 alleles are reported for a locus, the patient is likely homozygous. Rare diagnostic errors can occur due to primer site mutations. Occasionally the specific allele cannot be determined; in this case, the most likely allele assignment is made followed by a sequence of letters indicating other possible allele assignments. Interpretation of allele codes can be found at http://bioinformatics.nmdp.org/HLA/alpha.html.
Test Results: Results are reported as HLA locus B* followed by the two digit serologic antigen equivalent and the two digit assigned allele.
Analyte Specific Reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by HistoGenetics Inc (ASHI accreditation #03-1-NY-26-2). It has not been approved or cleared by the U.S. Food and Drug Administration. This test should not be considered as investigational or for research use. Test is performed at Histogenetics Inc.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.
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| Note: |
HLA Class I Sequencing is intended to identify HLA allelic polymorphisms at the level of individual nucleotides using genomic DNA amplified by PCR.
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| CPT Code(s): |
83891 Isolation; 83898 Amplification; 83904 x3 Sequencing; 83909 Separation and identification; 83912 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
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Cross References: |
Disease Association HLA-B Typing (HLA-B Sequence)
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