Reference Interval:
By report
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| Interpretive Data: |
This panel is useful in the initial diagnosis of PNH and was developed according to recently published guidelines (Cytometry B Clin Cytom. 2010 Jul; 78(4):211-30); it includes diagnostic WBC analysis and high-sensitivity RBC analysis. WBC analysis is the most accurate measurement of the PNH clone size with a lower limit of detection of 0.1 percent PNH cells and uses FLAER, CD14, and CD24 as GPI-linked markers with CD15 and CD33 as lineage-specific markers. The high sensitivity RBC analysis has a lower limit of detection of 0.005 percent PNH cells and quantifies Type II and Type III RBC populations when the percentage of PNH RBCs is greater than 1 percent. Glycophorin A is used to gate the RBC population. CD59 is the GPI-linked antigen. Recent RBC transfusions may decrease the percentage of PNH cells. (Cytometry 42:223-33, 2000).
This test also detects minor (0.005-0.999 percent) PNH clone populations found in bone marrow failure disorders.
Refer to Statement A under Testing Information at http://www.aruplab.com.
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| CPT Code(s): |
86356 CD14; 86356 CD15; 86356 CD24; 86356 CD33; 86356 FLAER; 86356 CD59; 86356 Glycophorin
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Cross References: |
PI-Linked Antigens, RBCs, Monocytes and Granulocytes (Paroxysmal Nocturnal Hemoglobinuria Panel, RBC and WBC)
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